Clinical Nephrology, Dialysis and Transplantation is edited by HH Malluche, BP Sawaya, RM Hakim and MH Sayegh, renowned capacities in this field. Updated in 2004, the two volumes of Clinical Nephrology, Dialysis and Transplantation do not nearly reflect another nephrology textbook. Indeed, a new concept using a loose-leaf system is being advanced. There are chapters on essential hypertension, hypertension secondary to parenchymal renal disease, renal vascular hypertension, management of hypertension, and hypertension in children and adolescence. The book should be an essential asset for any nephrologist's office.
Hypertension is common in patients with kidney disease for a number of reasons, including retention, inappropriate action by the renin-angiotensin system, and overactivity of the sympathetic nervous system. Of all causes of hypertension, renal artery stenosis (narrowing) has attracted considerable attention, because it was once thought to be a rare cause of hypertension, but is now known to be the most common cause of secondary hypertension. In The Kidney and Hypertension, George Bakris and a host of international contributors examine all aspects of hypertension in the renal patient. A reference book covering specific and common topics in the area of kidney disease and hypertension, it is an essential guide to the effective management of the renovascular patient. It covers everything from how to properly measure blood pressure to the assessment and treatment of elevated blood pressure in high-risk groups such as dialysis patients and pregnant women. Kidney and Hypertension also thoroughly discusses reducing cardiovascular risk in people with kidney disease due to its role as a leading cause of death among kidney patients. Additionally, there is a chapter on diabetes and its role as a common cause of kidney failure. As an introduction to basic concepts in the treatment of hypertension, Dr. Bakris's book will serve as an excellent reference to nephrologists, cardiologists, and cardiovascular surgeons in their efforts to reduce the risks of advanced kidney disease and cardiovascular disease.
The field of hemodialysis is subject to constant transformations due to continuous advances in techniques, biomaterials and devices. Based on international surveys, objective evaluations of experts and recent clinical trials, the publication at hand pays special attention to the physiological aspects of treatments as well as practical questions in the dialysis unit. Taking into account recent developments, an international group of contributors addresses issues related to vascular access, epidemiology, inflammation, fluid management, uremic toxicity, treatment efficacy, advanced techniques, calcium/phosphate homeostasis, and correction of anemia. Focusing on basic and clinical aspects of innovative technology as well as on new therapeutic options, this publication is a most helpful tool for the clinician to keep abreast of developments in the field of hemodialysis.
During the past 40 years there have been major conceptual and technical advances in the domain of dialysis methods and renal/organ transplantation for long-term treatment of patients with End-Stage Renal Failure (ESRF). This now enables better defined, more selective strategies of treatment to be undertaken, according to patient-specific criteria such as age or underlying renal disease also taking into account the lifetime duration of these treatments. For many patients this implies necessary successive changes of mode of therapy depending on their availability, occurrence of medical/technical complications or failure and social environment and economic factors. This rationale has inspired the structure of this volume which is divided into four sections: 1/A descriptive overview of the various modes of renal replacement therapy (RRT): Extracorporeal dialysis/filtration, peritoneal dialysis, kidney and multi-organ transplantation. 2/Most appropriate indications and use of these methods, respective advantages, drawbacks and outcome in children, pregnant women and elderly patients. 3/ In diabetic patients and in patients with heredity/congenital diseases.4/ The ethical issues generated by this new domain in Medicine by limitations in treatment facilities or medical dilemas for acceptance, best technical choices, withdrawal or termination of RRT in individual patients. Finally, contributors from Eastern European Coutnries, Africa and Far Eastern Countries analyse the current status of RRT in their respective geographical area and the ways and means required for a wider implementation of RRT in thus far lesser economically developed countries where the great majority of the populations still have no access to these life-saving therapeutic procedures.
This comprehensive book combines a review of the basic physiology and pathophysiology of each renal disorder and disease entity with state-of-the-art medical management guidelines based on evidence and expert opinion. Each chapter focuses on the unique and frequently challenging circumstances in pediatric patients, which are oftentimes very different from those in adult patients. Starting with a logical approach to each individual problem as seen in the ICU, it covers the pathophysiology of the child, the diagnostic approach and gives valuable up-to-date treatment recommendations. Health-care providers in all areas of care and all levels of training will find this unique book helpful. Those new in the field can use it as a beginner’s guide to become familiar with certain topics and those more advanced in their medical career will gain useful hints and find updated information on specific clinical disease entities.
This work gives an introduction to all aspects of drug use in renal failure."Introduction to Renal Therapeutics" is an introduction to all aspects of drug use in renal failure. Covering various diseases affecting the kidneys, each chapter discusses the disease process and treatment. It also addresses the role of the pharmacist in patient care. Case studies and questions and answers are included at the end of each chapter.Written by members of the UK Renal Pharmacy Group, this book will be of particular interest to anyone new to, or planning a career in, renal pharmacy. It will also be of interest to nonspecialists who deal with renal patients and to pharmacy students, and to any healthcare professional with an interest in renal medicine.
All you need to know about vascular and peritoneal access techniques Recent developments have spurred a renewed interest in novel solutions to access the patient circulation, mainly concentrating on vascular access for renal replacement therapies and on peritoneal dialysis access. Starting with the epidemiology, the focus then shifts to the evolution of new techniques and monitoring procedures with regard to hemodialysis, which are discussed and evaluated. Attention is also paid to the new biomaterials available, concentrating on their improved biocompatibility and surface characteristics. As developments in the field of peritoneal dialysis have taken a similar turn, new devices providing access to the peritoneal cavity which have recently been made available are introduced next. Last but not least, the management of complications and the continuous maintenance and care of the access with regard to both hemodialysis and peritoneal dialysis are highlighted. This book provides a complete overview of the devices, catheters and methods currently available to ensure successful vascular and peritoneal access. Taking into account both the physiology of the extracorporeal circulation and the mechanisms of peritoneal dialysis with regard to the most adequate access techniques, this is a unique resource for clinicians, investigators and researchers in the field of renal replacement therapy.
Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge.
Nolph and Gokal's Text Book of Peritoneal Dialysis, Third Edition, covers advances made in the field for the past 30 years. During the past two decades, the time during which this therapy has been increasingly utilized, this text has continued to be recognized as the major source of the discipline's base knowledge. The evolution of this text to its newest edition parallels the growth of peritoneal dialysis from Continuous Ambulatory Peritoneal Dialysis in the eighties to the current therapy that encompasses manual and automated therapies with full emphasis on adequacy of dialysis dose.
Peritoneal dialysis represents an intracorporeal technique for blood purification. This unique dialysis system represents one of many human attempts to manipulate nature for sustenance of life. The past few years of advances have focused on further improvement of the technique. Areas that have fueled the interest of researchers include: (1) Physiology of high transporters (and the role of genetics and inflammation); (2) Continued debate over the most appropriate adequacy indices (small solute clearances, large solute clearances, clinical assessment etc.); (3) Understanding, preventing and treating the MIA syndrome in PD patients ( including the roles of leptin, and adiponectin); (4) Pathogenesis and newer management strategies of vascular calcification; (5) Continued improvements in infectious complications including peritonitis; (6) Further improvements in catheter technology; (7) Automated techniques; (8) Explaining and correcting PD underutilization; (9) Rationale and applications of newer dialysis solutions; (10) New understanding and approaches to management of osteodystrophy; (11) Refinements in anemia management including new insights in iron metabolism in PD patients; (12) Further definition of indications for PD; (13) The ideal time to initiate dialysis.
Newer insight into host defense mechanisms have also made the past decade of advances in the field more meaningful for clinicians. This text also covers the knowledge gained from animal models of peritoneal dialysis.
Nolph and Gokal's Textbook of Peritoneal Dialysis, Third Edition is a compilation of the latest knowledge in the field. It cites and describes in great detail, the new discoveries and the evolution of understanding the subject of these discoveries.
