Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, "arming" mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.
The immuno-compromised patient is more susceptible to a broader range of infections than others, and infections of the respiratory tract are among the first and most common to be encountered.
In this book the authors review current options for management for a group of patients that present unique challenges to the clinician, and for whom the choices of effective therapy are often limited.
Most up to date book available dedicated specifically to this topic Major management issue in respiratory medicine for critical care, transplant and cancer patients Reviews important new advances in therapeutics, including drug resistance
This authoritative, single-source reference provides comprehensive examinations of the complement system;offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases. Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease describes the molecular architecture of the complement system details the structure of complement genes discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway elucidates the regulation of complement gene expression and the structure and function of bioactive peptides explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria and more!
HIV/AIDS management poses many different challenges around the world, and the therapies available in the West are often not economically feasible in developing countries. This new book is the first to address the myriad of clinical difficulties faced by health practitioners worldwide in managing HIV/AIDS. Edited by the same authorities responsible for the highly respected reference "The Medical Management of AIDS," with Associate Editors that include the President of the International AIDS Society and a preeminent opinion leader in the fight against AIDS in Africa, and authored by a "who's who" of current global experts on HIV and AIDS medicine, this visionary text presents all the practical, indispensable information that clinicians everywhere need to offer their patients the best possible care.
Access reliable, up-to-the-minute guidance that addresses the realities of HIV/AIDS management in your geographical region, thanks to contributions from a global cast of renowned expert clinicians and researchers. Locate the clinically actionable information you need quickly with an organization that mirrors the current state of the AIDS epidemic and the different needs of Western vs. developing-world patients and clinicians. Diagnose AIDS manifestations confidently by comparing them to full-color clinical images. Review essential data quickly through numerous at-a-glance tables.
Recent advances in immunology and molecular biology have resulted in new therapeutic approaches being generated and implemented in cancer clinics. The discovery of new antigens, mechanisms of antigen presentation, and interplay of cells involved in anti-tumor immunity have made the clinical control of some cancers more plausible than previously thought. An invaluable source for clinicians, researchers, and students, Tumor Immunology presents an introductory overview of the immunology of cancer including therapeutic approaches. Topics covered include the immune recognition of cancer-tumor antigens, humoral recognition of cancer, and the immunotherapy of cancer.
A tremendous amount of progress in understanding primary immune deficiencies has been made in the past few years. Developments in molecular biology have strengthened our understanding of differentiation and maturation of B cells and the biosynthesis of immunoglobulins, and have identified a number of genetic defects as the basis of primary immune deficiencies. Although such progress in molecular medicine seems to overshadow the spectrum of therapeutic options, IVIG remains a fundamental therapy. Drawing on papers presented at the recent Interlaken IVIG International Symposium, Intravenous Immunoglobulins In the Third Millennium provides a highly authoritative review of the pharmacology and therapeutic use of this agent. Written by an internationally recognized team of expert scientists and clinicians, the book reviews the major challenges and achievements in manufacturing, pathogen safety, clinical use, and mechanisms of action of IVIG and highlights the major recent and ongoing research in the field. A comprehensive update, the book is a valuable source of information on IVIG.
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events.
This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
In medical practice there are often complex cases that make extraordinary demands on a clinician’s knowledge and ingenuity. In Challenging Cases in Allergy and Immunology, the authors provide these types of fascinating, and informative cases to complement a basic knowledge of diagnosis and management in these fields. As such, this novel title will be of interest to a wide array of allergists and clinical immunologists, as well as all students of medicine and allied health. Written by a multidisciplinary group of national and international experts, the book covers in detail two or more challenging, real-life cases in each disorder discussed. Each case is followed by a work-up, treatment plan, and discussion that includes a differential diagnosis, up-to-date references, and up to ten thought-provoking, multiple-choice questions that enhance the book’s value as a comprehensive reference and teaching text. The cases include not only the common allergic diseases such as allergic rhinitis, asthma, and food allergy, but also disorders in immune regulation, autoimmunity, and immunodeficiencies. There are chapters on subjects as wide-ranging as anaphylaxis, occupational asthma, and immune-mediated rheumatic diseases. State-of-the-art and evidence-based, Challenging Cases in Allergy and Immunology is an important resource for all clinicians searching for ways to improve their ability to diagnose and manage patients with allergic and immunologic problems.
Basophils and mast cells are similar but unique secretory cells which play a central role in inflammatory and immediate allergic reactions. In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. The secretory granules and lipid bodies present in these cells are established as different, important organelles. A number of standard and newly developed ultrastructural imaging methods are described which define the subcellular locations of chymase, Charcot-Leyden crystal protein, histamine, and heparin as well as materials important in arachidonate and RNA metabolism, and in cytokine biology in basophils and mast cells. The findings presented elucidate new aspects of the secretory mechanisms of basophils and mast cells, their recovery, and the transepithelial route.
This helpful guide offers a wealth of information for individuals who have been diagnosed with HIV and for people caring for HIV positive friends and loved ones. It covers the entire HIV lifespan, from prevention to diagnosis and beyond. Valuable tips help the reader make the best decision when choosing a doctor, finding and adhering to the right medication regimen, and, if necessary, making end-of-life plans. All aspects of HIV/AIDS are discussed, including opportunistic and associated infections, dental care, exercise and nutrition, substance use and abuse, and emotional treatment.
