This leading text reflects both the new direction and explosive growth of the field of hematology. Edited and written by practitioners who are the leaders in the field, the book covers basic scientific foundations of hematology while focusing on its clinical aspects. This edition has been thoroughly updated and includes ten new chapters on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more. The table of contents itself has been thoroughly revised to reflect the rapidly changing nature of the molecular and cellular areas of the specialty. Over 1,000 vivid images, now all presented in full color for the first time, include a collection of detailed photomicrographs in every chapter, selected by a hematopathology image consultant. What's more, this Expert Consult Edition includes access to the complete contents of the book online, fully searchable.
* A multidisciplinary approach from a unique team of specialists delivers well-rounded guidance on every topic. * "Red boxes" present the authors' unique personal strategies for diagnosis and treatment. * An intuitively re-designed table of contents makes information easier than ever to find. * Online access allows you to rapidly search the entire contents of the book. * Regular online updates personally overseen by Dr. Hoffman keep you apprised of important new developments. * Ten cutting-edge new chapters - on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more - keep you completely current. * More than 1,000 vibrant images, all presented in full color for the first time, include a collection of detailed photomicrographs in several chapters selected by a hematopathology image consultant. * An enhanced clinical focus makes actionable information easier to find and apply. * Enhanced coverage of pediatric hematology reflects the supervision of new section editor Helen Heslop, MD, FRCPA, FRACP.
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This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
Studied since the 1930s, Vitamin K is a fat-soluble vitamin available primarily in vegetable sources. Vitamin K in Health and Disease provides a comprehensive summary of the latest scientific evidence regarding Vitamin K’s health-promoting activities. This book offers complete coverage of the chemistry of Vitamin K, deficiency signs and nutritional assessment, metabolism and biochemistry, and pharmacology. It presents up-to-date scientific studies on the nutritional, metabolic, and medical aspects along with an overview of the history of Vitamin K research. This text also reviews current dietary requirements and discusses both plasma and non-plasma Vitamin K-dependent proteins.
Targeted therapies are the focus of much research in oncology. Encouraging results from the development of new monoclonal antibodies are revolutionizing clinical therapies and this is particularly the case for haematologic malignancies. The advent of immunotherapy heralds a new era particularly for patients who are refractory to more traditional therapies. Impressive results are evident using monoclonal antibodies (mAb) that a) bind with high specificity to cell-surface antigens, resulting in targeted killing of the malignant cells or b) are conjugated to radioisotopes, toxins, enzymes or drugs that have the potential to reach high concentration at the tumour site. Not only do these agents improve remission and overall survival, but also many new studies have shown that they can be even more effective when used in combination with more traditional therapies. This unique book brings together a series of topical discussions of how the new immunotherapeutic agents can be used successfully to treat lymphoid malignancies. The contributors are prestigious clinicians and researchers working at the cutting edge of the field. This will be an invaluable resource for the haematologist or oncologist who will find up-to-date data and clinical advice regarding the latest immunotherapeutic options in haematology.
This ABC has established itself as a popular introduction to Clinical Haematology, relevant both for postgraduate students and primary care practitioners. Now in its third edition, the ABC of Clinical Haematology has been thoroughly revised, featuring the latest treatments for leukemia, antithrombotics and drugs for lymphoma and covering the latest advances in hematology and bone marrow transplantation.
With each chapter written by specialists in their respective fields, this is an ideal basic text for general practice and hospital staff with patients who have blood related problems, in particular GPs, hematology nurses, junior doctors, hematologists, and trainees in hematology.
Haematology at a Glance provides a concise and accessible introduction to haematology. It follows the easy-to-use 'at a Glance' format of double-page spreads comprising clear, memorable diagrams illustrating the key facts and essential textual information. It starts with an explanation of normal blood cells and routine laboratory tests. It then reviews a wide range of blood disorders. This new edition of Haematology at a Glance: * Contains full colour throughout * Presents the key facts accompanied by clear diagrams, photos and images * Highlights the most recent developments in the field, including coverage of transplantation technology * Includes new chapters on : * The side affects of drug treatment * Pregnancy and neonatological aspects of haematology * Practical procedures Haematology at a Glance will appeal to medical students, junior doctors on foundation programmes, haematology technicians and nursing and other health care students with an interest in haematology.
Edited and written by world authorities, this text encompasses all aspects of Hodgkin's disease, non-Hodgkin's lymphomas, and related disorders. Designed to be the "Bible" for both clinicians and scientists who deal with lymphoma, the book is packed with useful summary tables and abundant illustrations and translates cutting-edge discoveries into state-of-the-art management guidelines. The preeminent names in research and practice bring together today's entire spectrum of knowledge--from epidemiology, classification and prognosis through diagnosis and therapy, including the latest scientific advances, such as the impact of molecular biologic and genetic discoveries and new biologic markers.
One of the major breakthroughs in the treatment of cardiovascular disease is the introduction of fibrinolytic therapy. Better knowledge of the pathogenesis of acute ischemic syndromes has identified acute thrombosis as the triggering event in most cases. Thrombosis of large and small arteries may have catastrophic consequences as sudden death, myocardial infarction, ischemic stroke, pulmonary embolism and acute limb necrosis. Fibrinolytic therapy is aimed at early restoration of occluded blood vessels, thus improving symptoms and organ recovery, reducing infarct size and improving quantity and quality of life. However, fibrinolytic drugs have severe, sometimes fatal side-effects. These center on bleeding, sometimes fatal cerebral bleeding. Therefore, stringent patient selection is mandatory; age, time to treatment, relative and absolute contraindications and comitant medication are of utmost importance for safe and efficacious fibrinolysis.
