Bringing together contributions from many of the world's leading experts in toxinology, the Handbook of Venoms and Toxins of Reptiles covers a broad range of topics relevant to a wide range of professionals including clinicians, biomedical researchers, herpetologists, and zoologists, as well as pharmacologists and evolutionary scientists. It discusses phylogeny and gland structure, venom enzymes and toxins, non-protein venom components, and envenomation and its treatment, including ideal treatments contrasted with that which is actually available in specific areas of the world. The text also addresses venom enzymes and assay procedures used to detect venoms along with venom toxins.
Concise and authoritative, Clinical Toxicology: Principles and Mechanisms examines the complex interactions associated with clinical toxicological events and chemical exposure or drug administration. The author places special emphasis on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. He covers contemporary issues in clinical toxicology, such as biological and chemical toxins, changes in protocols for managing toxic ingestions, new antidotes, changes in particular treatments, and pharmacology and toxicology of herbal products. After introducing the fundamental principles of toxicology, the book presents the toxicity of therapeutic and non-therapeutic agents in separate sections. Most chapters start with a basic review of the general physiology and pharmacology principles necessary for understanding the underlying mechanisms of toxicity. The book includes numerous drawings, figures, and tables that improve understanding of the mechanisms involved in chemical exposure. It covers widely distributed chemical agents and currently used therapeutic drugs that possess hazardous effects either as principle mechanisms of action or as untoward adverse drug reactions. A reader-friendly exposition of clinical toxicology, Clinical Toxicology: Principles and Mechanisms can be used as a stand-alone text or a professional reference.
A unique reference containing detailed reviews of more than 900 drugs and poisons, the Poisoning and Toxicology Handbook, Fourth Edition provides the latest information on medicinal, biological, herbal, and non-medicinal agents, and antidotes. Increasing its depth and scope with analyses of newer drugs, chemicals, and environmental toxins, including drugs that have been recently approved by the FDA, the book is a compendium of useful resources. Organized into seven sections, the book provides locations and phone numbers of poison control centers throughout the country, organizations offering information on toxicology, and teratology information services. It presents diagnostic testing and analytical procedures, evaluates the effectiveness of antidotes, and features an extensive symptoms index. The section on special topics provides detailed treatment protocols, hospital preparedness guidelines, and position statements and practice guidelines focused on the treatment of toxicities. This fourth edition keeps you up to date in one of the most exciting and expanding fields in medical science.
Originally published to provide quick and portable access to the most frequently needed information in the original bestselling CRC Handbook of Toxicology, this new pocketbook is designed to serve the same purpose for the recently revised and expanded Handbook. It continues to provide the most frequently used toxicological reference material in a convenient pocket-sized format. Several sections have been expanded to offer important new information and meet current and emerging areas of concern. A great number of new tables have been added and a few less useful ones eliminated. It also includes a much more timely and reformatted glossary.
About 40% of central nervous system synapses use glutamate as the neurotransmitter. Over-stimulation of glutamate receptors produces neuronal injury or death by excitotoxicity, which is closely associated with neurochemical and neuropathological changes involved in acute neural trauma (stroke, spinal cord trauma, and head injury) and neurodegenerative diseases such as Alzheimer disease, Parkinson disease , Huntington disease, amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease, Guam-type amyotrophic lateral sclerosis/Parkinson dementia (ALS/PDC), and multiple sclerosis.
In the past decade, our understanding of the biochemistry, molecular biology, and neuropathology of the glutamate transporters and receptors has exploded. It is becoming increasingly evident that molecular mechanisms, which govern the transfer of the death signal from the neural cell surface to the nucleus, depend on lipid mediators and on cross talk among excitotoxicity, oxidative stress, and neuroinflammation, and that interactions among these three processes play a major role in neuronal cell death during acute neural trauma and neurodegenerative disease. These processes may be primary initiating points in neurodegeneration or they may be the end result of the neurodegenerative process itself.
Neurochemical Aspects of Excitotoxicity provides extensive insight into glutamate transporters and receptors, including their role in the brain with other neurochemical parameters in excitotoxicity, and possible treatments. This book will be of interest scientists already working in the field of excitotoxicity who are interested in gaining a broader understanding of this complicated subject area, as well as graduate students and neurologists who are curious about a common cause of neuronal injury and neurological disorders.
In the 20 years that have passed since the publication of the first edition, both Poison Control Centers and Emergency Departments have witnessed an expansion in the number and variety of poisonings caused by toxic plants. At the same time, there is a proliferation in the diversity of plants in our gardens and homes, continually expanding the range of possible consequences from exposure to toxic plants.
This second edition of the Handbook of Poisonous and Injurious Plants is created to assist the clinician in the initial response to the needs of a child or adult exposed to a poisonous or injurious plant. It lists common plants that might lead to the development of the symptom complex and describes the mechanisms of action of the implicated toxin, additional clinical manifestations, and specific therapeutics for each presentation. It has methodically enhanced the previous editions botanical rigor with insights from both pharmacognosy and clinical medicine to make it a truly comprehensive source.
With its thorough references and full-color photos of hundreds of potentially toxic and injurious plants inside the home, anyone who has an interest in plants will find this book useful outside in the garden or out in the wild.
This book will fascinate botanists, horticulturists, and naturalists as well as hikers, gardeners, and all those who simply enjoy the wonders of nature and the great outdoors!
Product Description: * Pertaining to homeland security, this title is a comprehensive guide to radiation protection caused by accidents or terrorism * Provides essential strategies and guidance for protecting ports and examines the latest nuclear detection devices that can be deployed * Explains the procedures in FEMA's "National Incident Management System" * Gives specific details for first responders and emergency workers on how to prepare for and handle radiological incidents
In biological systems, the normal processes of oxidation (plus a minor contribution from ionising radiation) produce highly reactive free radicals. These can readily react with and damage other molecules. In some cases the body uses free radicals to destroy foreign or unwanted objects, such as in an infection. However, in the wrong place, the body's own cells may become damaged. Should the damage occur to DNA, the result could be cancer. Antioxidants decrease the damage done to cells by reducing oxidants before they can damage the cell. Virtually all studies of mammals have concluded that a restricted calorie diet extends the lifespan of mammals by as much as 100 percent. This remarkable finding suggests that food is actually more damaging than smoking.As food produces free radicals (oxidants) when metabolised, antioxidant-rich diets are thought to stave off the effects of ageing significantly better than diets lacking in antioxidants. The reduced levels of free radicals, resulting from a reduction in their production by metabolism, is thought to be a major cause of the success of caloric restriction in increasing life span. Antioxidants consist of a group of vitamins including vitamin C, vitamin E, selenium and carotenoids, (such as beta-carotene, lycopene, and lutein). This book brings together the latest research in this dynamic field.
