This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine Therapy in Breast Cancer · details modern techniques for molecular profiling, monitoring, and targeting · offers methods to identify high-risk groups · evaluates molecular biomarkers in breast cancer assessment · examines the potential toxicity of estrogen receptor (ER)-directed endocrine therapy · investigates the development of endocrine resistance · discusses neoadjuvant and preoperative approaches in patient care · reviews mechanisms that lead to estrogen-independent phenotypes Surveying the medical, surgical, and pathological aspects of endocrine therapy, as well as future research opportunities, Endocrine Therapy in Breast Cancer is a concise and in-depth manual for medical, surgical, and radiation oncologists; endocrinologists; gynecologists; obstetricians; pharmacologists; family physicians; reproductive biologists; epidemiologists; and medical school students.
Pharmacogenetics, generally referred to as the study of genetic variation that gives rise to differing response to drugs, is becoming more relevant in the diagnosis, treatment, and recovery of cancer patients. The problem faced when treating cancer is the outstanding varied efficacy between success and failure. Unpredictability between a population of patients who are affected with the same occurring malignancy can show varying associated toxicities in drug treatment ranging from zero effect through lethal doses. Since the chemotherapeutic agent is often developed to fit the average patient the unfortunate result is that approximately 40% of patients may be receiving the wrong drug. However, using pharmacogenetics there are promising advancements in the development of effective agents which will enable ‘personalized cancer chemotherapy’ to become routine for the clinical practice. This individualization is most advanced in the field of breast cancer; while many breast oncologists are individualizing techniques based on specific profiles, within 10 years it is likely all breast oncologists will be using RT-PCR, FISH-based multiplexed arrays, or a similar testing regime for patient individualization therapy.
This book discusses the principles and practice of breast cancer management within the context of multidisciplinary team working and places emphasis on pragmatism. The text provides a comprehensive and contemporary account of the subject and should permit the reader to develop a firm understanding of the disease from epidemiology, genetics and screening, to pathology, diagnosis, treatment, and prevention. This in turn will enable healthcare personnel to deliver a high quality and up-to-date service to breast cancer sufferers.
This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in understanding the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in diagnosis, genetics, screening, prevention, and management. In addition, the volume discusses ethical and insurance issues, distinct cultural differences in breast cancer and use of recently devised cancer genetics clinics. The different referral criteria and patterns to these clinics are detailed.
The first edition of this groundbreaking text established itself as the definitive reference on a topic of extreme interest and relevance to those involved in breast cancer management. This new Second Edition is filled with over 250 full-color images, illustrations, and photographs, and showcases cutting-edge translational research not included in the first edition. The broader scope of information in this text is essential reading for gynecologic surgeons, oncologists, pathologists, and molecular biologists.
Fox Chase Cancer Center, Philadelphia, PA. Features state-of-the-art guidance on all forms of breast cancer treatment and reviews current controversies and on-going research in the field. Gives an evaluation of breast-conserving therapy with and without radiation therapy. DNLM: Breast Neoplasms--therapy.
This new publication discusses the significant advances in the study, investigation and treatment of breast cancer and surveys how scientific advances have influenced, improved, and extended modern therapeutic options. The volume spans prevention, screening, genetics, and treatment of pre-invasive breast cancer, before focusing in depth on modern management of established breast cancer. This volume includes chapters on the various therapeutic options available and their role in treating breast cancer from the very earliest stage through to advanced and metastatic breast cancer, as well as a chapter on palliative care. In addition, the text looks forward at the potential for emerging experimental strategies to become adopted into medical management in the future.
Covers all the recent advances in screening, helping with the assessment of symptoms, prognosis and treatments of breast diseases Breast diseases are becoming more and more common and health professionals in almost every field will probably come into contact with a patient who has a breast disorder. This third edition provides an account of the current knowledge on benign and malignant breast conditions and the treatment of them. It covers all the recent advances in screening and adjuvant treatment, including the new aromatase inhibitor clinical trials and improvements in metastatic disease treatment. New chapters on prognosis and clinical trials have also been added. Edited and written by experts in the field, this book appeals to a wide readership including general practitioners, practice nurses, breast care nurses, surgeons or oncologists in training, and medical students. It contains such a wealth of knowledge it will also be a valuable source of information for established breast surgeons and oncologists. Helping to assist the assessment of symptoms, prognosis and treatments of breast diseases.
There are an estimated 41,000 new cases of Uterine and Endometrial Cancer each year in the United States alone, resulting in roughly 7300 deaths. In Uterine Cancer: Screening, Diagnosis and Treatment, Franco Muggia, Esther Oliva and a panel of prominent medical and gynecologic oncologists survey all aspects of Uterine and Endometrial Cancer, including current screening methods, staging and prognostic factors, and available treatment options. The discussion includes the role of imaging in the diagnosis and treatment of endometrial cancer, the molecular pathology and genetics of uterine cancer and the essential epidemiology of cancer of the endometrium. Authoritative and highly practical, Uterine Cancer: Screening, Diagnosis and Treatment is the definitive text on the most common cancer of the female genital tract, and a must-have for all gynecological residents and fellows, as well as gynecological oncologists and family practice doctors who wish to provide their patients with the best possible care.
The Fourth Edition of Cancer Nursing is revised and updated to include the latest developments in oncology nursing and cancer patient care. The basic science chapters in Part I have been completely reorganized and rewritten to reflect the massive increase during the last few years in scientific knowledge about the relationship between genes and cancer. Every chapter has been updated with a focus on self-care, managed care, and ambulatory care and two new chapters, "Health Policy and Legislative Issues" and "The Role of the Advanced Practice Nurse" have been added. Additionally, there are expanded sections on bone marrow transplantation urologic tumors and survivorship. As with the previous editions, Cancer Nursing continues to present the most comprehensive information on oncology nursing with an extensive art program and references from leading cancer nursing experts.
