This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
This text is a detailed guide to the use of flow cytometry, immunohistochemistry, and molecular genetic techniques for diagnosis of hematologic neoplasms. Dr. Sun explains the principles of these techniques and demonstrates their utility in 39 clinical cases covering all important entities. Each case represents a comprehensive diagnostic approach including a clinical history and flow cytometric, immunohistochemical, and molecular genetic findings. Abundant full-color illustrations show histologic sections, immunohistochemical stains, bone marrow, peripheral blood, and body fluid smears, and each case includes a complete set of flow cytometric histograms. Over 100 tables compare and differentiate the diagnostic features of similar diseases.
Focusing on clinical issues as well as practical approaches to diagnosis and treatment recommendations, this collection represents a practical guide to the pathogenesis, recognition and management of hematologic problems in the neonate. Its contributions are written by practicing physicians specializing in pediatric hematology, neonatology, immunology, pediatric infectious disease and transfusion medicine.
PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
First edition won Best Book in Medical Science Award from the Association of American Publishers
Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias
A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts. The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF, HIF and eNOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors and NO). These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis.
Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.
Angiogenesis is an essential component of inflammation and its resolution. This volume provides up-to-date information on the latest developments in the pathology, mechanisms and therapy of angiogenesis dependent inflammatory disease. Recent years have seen large advances in angiogenesis research, especially in oncology. Traditionally mechanisms in inflammation angiogenesis were inferred from tumour angiogenesis, however recent research has matured highlighting the similarities and dissimilarities between these processes. This volume relates the lessons learned from tumour biology applied to inflammation. Angiogenesis in Inflammation: Mechanisms and Clinical Correlates develops current knowledge on the mechanisms at the molecular and cellular levels as they relate to inflammation, including acute and chronic inflammation, neurogenic initiation, and the role of the multiple cellular components that comprise inflammation: granulocytes, macrophages, fibroblasts, dendritic cells and lymphocytes. This is related to inflammatory diseases: not only the familiar angiogenesis dependent diseases of rheumatoid arthritis and psoriasis, but also loci such as the lung, gastric ulcers, the eye with uveitis, wound healing and periodontal disease and their therapy. The book shows how this knowledge may be used in the discovery of novel therapeutics. It brings together experts in each of these fields to link the molecular and cellular processes in angiogenesis to those of inflammation and disease, culminating in a discourse on areas for future therapies.
This unique and practical book introduces the reader to the concept of blood management and explains how to improve patient outcomes by avoiding undue blood loss, enhancing the patient’s own blood, effective management of anemia and coagulopathy. Basics of Blood Management is the first book dedicated to blood management, a multidisciplinary and multimodality concept that focuses on patient outcome. A practical and comprehensive text on the new and exciting field of blood management * Takes an international perspective, covering conditions encountered in developing and industrial countries * Covers all areas of organization, methods and tools * Gives the reader an understanding of the concept and philosophy of blood management * Provides clinical scenarios and exercises that help the reader to adapt information for their location
Whether you are an early practising clinician in hematology, transfusion, critical care, anesthesiology, surgery or internal medicine, a nursing specialist, trainee or other member of the multidisciplinary blood management team, this book will answer all your questions about blood management as an aid in improving patient outcome.
This extensive reference covering neoplastic hematopathology includes over 500 colour illustrations depicting hematopoietic tumors involving lymph nodes, spleen, bone marrow, and commonly affected extranodal organs, with special emphasis on the differential diagnosis. It discusses basic clinical, prognostic, morphologic and phenotypic data, with numerous tables summarizing the phenotypic profiles of the most common hematologic tumors. A major feature of this book is an approach to hematologic tumors based on the WHO classification, with relevant examples and emphasis on the most useful morphologic and immunophenotypic features used in diagnosis. It will be an invaluable reference for all practising hematologists, oncologists and pathologists.
With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, Informa Healthcare with Dr. Mughal and Dr. Goldman discuss the state-of-the-art advancements and new and existing implications in the diagnosis, treatment, and management of patients.
Filled with innovative information relating to stem-cell transplantations and full color photography, this well-illustrated text will be an essential resource for all practitioners in hematologic oncology.
